I spent a few minutes digging in my yard all in the name of cancer research.

There is rainwater seeping into my jeans, and my instructions are about to blow away. But my front yard could hold the cure to cancer, so I keep digging.

I am outside my home in Portland, Oregon, digging in the soil with a small plastic scoop I requested from the Natural Products Discovery Group at the University of Oklahoma. An interdisciplinary team of researchers are hard at work there, looking for fungi and natural products found in soil that may be used for a host of drugs and cures for cancer, infectious diseases, and even heart disease.

So the least I can do is get my knees wet.


That's me, going full science. Photo by Margaret Ryan for Welcometoterranova.

It sounds like something from the future, but natural products have been used in drugs for thousands of years.

Soil is packed with teeny, tiny living elements, including millions of fungi. You can't see them without a microscope, but they're really good at making and emitting new compounds called natural products. And these natural products may be the microscopic molecules researchers need to slow down growing cancer cells or stop deadly pathogens in their tracks.

But this isn't an entirely new concept.

"On the one hand, people will argue that humans have been using natural products for millennia," said Dr. Robert Cichewicz, principal investigator for the Natural Products Discovery Group, before telling me about the poison that killed Socrates. But he admits modern scientists have been using natural products to create drugs since the turn of the 20th century.

And they've come a long way since then.

A researcher assessing soil. Photo via Dr. Robert Cichewicz/NPDG/University of Oklahoma, used with permission.

Since soils are home to so many fungi and natural products, researchers at the Natural Products Discovery Group have one of the dirtiest jobs in the biz.

A biologist and natural products expert, Cichewicz leads a team of researchers assessing soils to identify promising fungi and natural products that could be turned into compounds and maybe one day, life-saving drugs.

"[Drugs] aren't just created out of the thin air in a laboratory. It's a process," Cichewicz said. "Natural products have a long history of supplying roughly half of the drugs that are prescribed today. So we're continuing that search."


Hard at work in the laboratory, studying fungi. Photo via Dr. Robert Cichewicz/NPDG/University of Oklahoma, used with permission.

Cichewicz and his team assess soil samples from all across the country to look for natural products that appear promising for slowing down cancer, attacking microbial infections, and inhibiting parasitic diseases.

The fungi and natural products can vary widely from neighbor to neighbor, or even front yard to backyard, so every sample counts.

"What we look at as a homogeneous yard is really a complex matrix of different types of micro-environments," Cichewicz said.

This is where you — yes, you! — and your matrix of a yard come in.

Photo by Margaret Ryan for Welcometoterranova.

Cichewicz and his team are looking for soil samples from citizen scientists, no Ph.D. required.

The team is looking for people to take soil samples from their yards for use in their research. Individuals across the country can participate and request a free collection kit online. The kit includes instructions, a small scoop, a plastic bag for your sample, and a pre-paid envelope to mail your soil back.

Mine arrived two business days after I submitted my request online, and I soon found myself hard at work in my front yard. Short of a couple of soggy knees, collecting the sample was easy.

Just use the supplied scoop to get a few tablespoons of soil.

Photo by Margaret Ryan for Welcometoterranova.

Then seal the bag tight before placing it in the pre-paid envelope.

Photo by Margaret Ryan for Welcometoterranova.

You also have to answer a few questions about your soil, but it's nothing too tricky.

Photo by Margaret Ryan for Welcometoterranova.

Once you submit your sample, you'll be able to track it online and eventually see the types of fungi and natural products found in your soil. It's a rare chance to get a closer look at what's under your feet every day, and it's a chance for you to play an active role in some amazing research.

A picture of the samples as they move through the testing process, which can take up to a year. Photo via Dr. Robert Cichewicz/NPDG/University of Oklahoma, used with permission.

The best part? Fungi from your soil could end up at the National Cancer Institute.

Cichewicz is working with the National Cancer Institute to make the entire collection of fungi free to researchers.

This means researchers or teams with different goals — whether it's drugs and cures for Alzheimer's, heart disease, or Parkinson's — wouldn't need to start their own collection from scratch.

"Natural products as a field has traditionally involved everybody going their own way, finding their own organisms whether they're in the jungles of South America, the frigid waters of Antarctica, or right here in Oklahoma," Cichewicz said. "This would be really a game-changer, in that, 'Here's a collection. Focus on producing new drug leads.'"

Access to this fungi library could save countless amounts of time and money and frees up the nation's top researchers to do what they do best: find compounds that work.

Photo via Dr. Robert Cichewicz/NPDG/University of Oklahoma, used with permission.

I sealed my soil and survey in the envelope and rested it gingerly on my kitchen table. After all, it's precious cargo.

Photo by Margaret Ryan for Welcometoterranova.

Later, on my walk to the mailbox, I caught myself looking closely at my neighbors' yards for the first time. What secret does their soil hold? Maybe those flowers are so tall because they're rooted in possibility. Is there a cure for Alzheimer's under those cherry blossoms?

Maybe. Maybe not.

But since many of us know or will know someone who could benefit from this vital research, it can't hurt to look.

Courtesy of Macy's

Brantley and his snowman

True

"Would you like to build a snowman?" If you asked five-year-old Brantley from Texas this question, the answer would be a resounding "Yes!" While it may sound like a simple dream, since Texas doesn't usually see much snow, it seemed like a lofty one for him, even more so because Brantley has a congenital heart disease.

On Dec. 11, 2019, however, the real Macy's Santa and his two elves teamed up with Make-A-Wish to surprise Brantley and his family on his way to Colorado where there was plenty of snow for him to build his very own snowman, fulfilling his wish as part of the Macy's Believe campaign. After a joy-filled plane ride where every passenger got gift bags from Macy's, the family arrived in Breckenridge, Colorado where Santa and his elves helped Brantley build a snowman.

Brantley, Brantley's mom, and Santa marveling at their snowmanAll photos courtesy of Macy's

Brantley, who according to his mom had never actually seen snow, was blown away by the experience.

"Well, I had to build a snowman because snowmen are my favorite," Brantley said in an interview with Summit Daily. "All of it was my favorite part."

This is just one example of the more than 330,000 wishes the nonprofit Make-A-Wish have fulfilled to bring joy to children fighting critical illnesses since its founding 40 years ago. Even though many of the children that Make-A-Wish grants wishes for manage or overcome their illnesses, they often face months, if not years of doctor's visits, hospital stays and uncomfortable treatments. The nonprofit helps these children and their families replace fear with confidence, sadness with joy and anxiety with hope.

It's hardly an outlandish notion — research shows that a wish come true can help increase these children's resiliency and improve their quality of life. Brantley is a prime example.

"This couldn't have come at a better time because we see all the hardships that we went through last year," Brantley's mom Brandi told Summit Daily.

Brantley playing with snowballs

Now more than ever, kids with critical illnesses need hope. Since they're particularly vulnerable to disease, they and their families have had to isolate even more during the pandemic and avoid the people they love most and many of the activities that recharge them. That's why Make-A-Wish is doing everything it can to fulfill wishes in spite of the unprecedented obstacles.

That's where you come in. Macy's has raised over $132 million for Make-A-Wish, and helped grant more than 15,500 wishes since their partnership began in 2003, but they couldn't have done that without the support of everyday people. The crux of that support comes from Macy's Believe Campaign — the longstanding holiday fundraising effort where for every letter to Santa that's written online at Macys.com or dropped off safely at the red Believe mailbox at their stores, Macy's will donate $1 to Make-A-Wish, up to $1 million. New this year, National Believe Day will be expanded to National Believe Week and will provide customers the opportunity to double their donations ($2 per letter, up to an additional $1 million) for a full week from Sunday, Nov. 29 through Saturday, Dec. 5.

There are more ways to support Make-A-Wish besides letter-writing too. If you purchase a $4 Believe bracelet, $2 of each bracelet will be donated to Make-A-Wish through Dec. 31. And for families who are all about the holiday PJs, on Giving Tuesday (Dec. 1), 20 percent of the purchase price of select family pajamas will benefit Make-A-Wish.

Elizabeth living out her wish of being a fashion designer

Additionally, this year's campaign features 6-year-old Elizabeth, a Make-A-Wish child diagnosed with leukemia, whose wish to design a dress recently came true. Thanks to the style experts at Macy's Fashion Office and I.N.C. International Concepts, only at Macy's, Elizabeth had the opportunity to design a colorful floral maxi dress. Elizabeth's exclusive design is now available online at Macys.com and in select Macy's stores. In the spirit of giving back this holiday season, 20 percent of the purchase price of Elizabeth's dress (through Dec. 31) will benefit Make-A-Wish.You can also donate directly to Make-A-Wish via Macy's website.

This holiday season may be a tough one this year, but you can bring joy to children fighting critical illnesses by delivering hope for their wishes to come true.

Usually when we share a story of a couple having been married for nearly five decades, it's a sweet story of lasting love. Usually when we share a story of a long-time married couple dying within minutes of each other, it's a touching story of not wanting to part from one another at the end of their lives.

The story of Patricia and Leslie "LD" McWaters dying together might have both of those elements, but it is also tragic because they died of a preventable disease in a pandemic that hasn't been handled well. The Michigan couple, who had been married for 47 years, both died of COVID-19 complications on November 24th. Since they died less than a minute apart, their deaths were recorded with the exact same time—4:23pm.

Patricia, who was 78 at her passing, had made her career as a nurse. LD, who would have turned 76 next month, had been a truck driver. Patricia was "no nonsense" while LD was "fun-loving," and the couple did almost everything together, according to their joint obituary.

Keep Reading Show less
Courtesy of Macy's

Brantley and his snowman

True

"Would you like to build a snowman?" If you asked five-year-old Brantley from Texas this question, the answer would be a resounding "Yes!" While it may sound like a simple dream, since Texas doesn't usually see much snow, it seemed like a lofty one for him, even more so because Brantley has a congenital heart disease.

On Dec. 11, 2019, however, the real Macy's Santa and his two elves teamed up with Make-A-Wish to surprise Brantley and his family on his way to Colorado where there was plenty of snow for him to build his very own snowman, fulfilling his wish as part of the Macy's Believe campaign. After a joy-filled plane ride where every passenger got gift bags from Macy's, the family arrived in Breckenridge, Colorado where Santa and his elves helped Brantley build a snowman.

Brantley, Brantley's mom, and Santa marveling at their snowmanAll photos courtesy of Macy's

Brantley, who according to his mom had never actually seen snow, was blown away by the experience.

"Well, I had to build a snowman because snowmen are my favorite," Brantley said in an interview with Summit Daily. "All of it was my favorite part."

This is just one example of the more than 330,000 wishes the nonprofit Make-A-Wish have fulfilled to bring joy to children fighting critical illnesses since its founding 40 years ago. Even though many of the children that Make-A-Wish grants wishes for manage or overcome their illnesses, they often face months, if not years of doctor's visits, hospital stays and uncomfortable treatments. The nonprofit helps these children and their families replace fear with confidence, sadness with joy and anxiety with hope.

It's hardly an outlandish notion — research shows that a wish come true can help increase these children's resiliency and improve their quality of life. Brantley is a prime example.

"This couldn't have come at a better time because we see all the hardships that we went through last year," Brantley's mom Brandi told Summit Daily.

Brantley playing with snowballs

Now more than ever, kids with critical illnesses need hope. Since they're particularly vulnerable to disease, they and their families have had to isolate even more during the pandemic and avoid the people they love most and many of the activities that recharge them. That's why Make-A-Wish is doing everything it can to fulfill wishes in spite of the unprecedented obstacles.

That's where you come in. Macy's has raised over $132 million for Make-A-Wish, and helped grant more than 15,500 wishes since their partnership began in 2003, but they couldn't have done that without the support of everyday people. The crux of that support comes from Macy's Believe Campaign — the longstanding holiday fundraising effort where for every letter to Santa that's written online at Macys.com or dropped off safely at the red Believe mailbox at their stores, Macy's will donate $1 to Make-A-Wish, up to $1 million. New this year, National Believe Day will be expanded to National Believe Week and will provide customers the opportunity to double their donations ($2 per letter, up to an additional $1 million) for a full week from Sunday, Nov. 29 through Saturday, Dec. 5.

There are more ways to support Make-A-Wish besides letter-writing too. If you purchase a $4 Believe bracelet, $2 of each bracelet will be donated to Make-A-Wish through Dec. 31. And for families who are all about the holiday PJs, on Giving Tuesday (Dec. 1), 20 percent of the purchase price of select family pajamas will benefit Make-A-Wish.

Elizabeth living out her wish of being a fashion designer

Additionally, this year's campaign features 6-year-old Elizabeth, a Make-A-Wish child diagnosed with leukemia, whose wish to design a dress recently came true. Thanks to the style experts at Macy's Fashion Office and I.N.C. International Concepts, only at Macy's, Elizabeth had the opportunity to design a colorful floral maxi dress. Elizabeth's exclusive design is now available online at Macys.com and in select Macy's stores. In the spirit of giving back this holiday season, 20 percent of the purchase price of Elizabeth's dress (through Dec. 31) will benefit Make-A-Wish.You can also donate directly to Make-A-Wish via Macy's website.

This holiday season may be a tough one this year, but you can bring joy to children fighting critical illnesses by delivering hope for their wishes to come true.

via Twins Trust / Twitter

Twins born with separate fathers are rare in the human population. Although there isn't much known about heteropaternal superfecundation — as it's known in the scientific community — a study published in The Guardian, says about one in every 400 sets of fraternal twins has different fathers.

Simon and Graeme Berney-Edwards, a gay married couple, from London, England both wanted to be the biological father of their first child.

"We couldn't decide on who would be the biological father," Simon told The Daily Mail. "Graeme said it should be me, but I said that he had just as much right as I did."

Keep Reading Show less
via Elliot Page / Instagram

Elliot Page, once publicly known as Ellen Page, has announced he is transgender. The announcement makes the Oscar-nominated actor one of the most high-profile celebrities to come out as transgender.

The actor currently stars in Netflix's "The Umbrella Academy" and has acted in films such as "Juno," "Inception," and the "X-Men" franchise.

Page made the announcement on social media where he celebrated the joy of coming out while taking the opportunity to discuss the issues faced by the transgender community.

Keep Reading Show less